Anti-Inflammatory and Anti-Nociceptive Activity of Disodium Glycyrrhetinic Acid Hemiphthalate

G. Khaksa; M. E. Zolfaghari; A. R. Dehpour; T. Samadian

doi:10.1055/s-2006-957894

Planta Medica, Table of Contents

Planta Med 1996; 62(4): 326-328
DOI: 10.1055/s-2006-957894

Papers

Anti-Inflammatory and Anti-Nociceptive Activity of Disodium Glycyrrhetinic Acid Hemiphthalate

G. Khaksa, M. E. Zolfaghari, A. R. Dehpour, T. Samadian

Pharmaceutical Research Center Darou Pakhsh Co., P.O. Box 13185-877, Tehran, Iran

Abstract

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Abstract

The anti-inflammatory and anti-nociceptive effects of disodium glycyrrhetinic acid hemiphthalate (glycyrrhetinic acid 3β-O-hemiphthalate sodium) after parenteral administration were determined in several animal models. Disodium glycyrrhetinic acid hemiphthalate (GAP) significantly inhibited the rat paw edema induced by carrageenin (ID₅₀ = 21.37 mg/kg), and mice writhing responses caused by acetic acid (ID₅₀ = 9.12 mg/kg). The potency of disodium glycyrrhetinic acid hemiphthalate was about 13.05 times higher than acetylsalicylic acid in inhibiting rat paw edema and 12.84 times higher in inhibiting abdominal constrictions in mice.

Key words

Non-steroidal anti-inflammatory agents - anti-nociceptive - carrageenin - glycyrrhetinic acid derivatives

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